BRD-K33272502_DG-041_U937_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K33272502_DG-041_U937_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
CLU clusterin
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
FHL1 four and a half LIM domains 1
GAB2 GRB2-associated binding protein 2
H1F0 H1 histone family, member 0
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IL15 interleukin 15
INPP1 inositol polyphosphate-1-phosphatase
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLK5 kallikrein-related peptidase 5
KYNU kynureninase
LGALS4 lectin, galactoside-binding, soluble, 4
LMO4 LIM domain only 4
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MET MET proto-oncogene, receptor tyrosine kinase
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
PPARG peroxisome proliferator-activated receptor gamma
PSAT1 phosphoserine aminotransferase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS13 regulator of G-protein signaling 13
RGS5 regulator of G-protein signaling 5
RNF114 ring finger protein 114
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC4 structural maintenance of chromosomes 4
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ASCL1 achaete-scute family bHLH transcription factor 1
C3 complement component 3
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CD3EAP CD3e molecule, epsilon associated protein
COPS7A COP9 signalosome subunit 7A
CYTL1 cytokine-like 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR3 early growth response 3
EMP2 epithelial membrane protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRSF1 G-rich RNA sequence binding factor 1
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
LAGE3 L antigen family, member 3
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
METTL13 methyltransferase like 13
MMP1 matrix metallopeptidase 1
MREG melanoregulin
MSLN mesothelin
NOP16 NOP16 nucleolar protein
NSG1 neuron specific gene family member 1
PLAT plasminogen activator, tissue
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SACS sacsin molecular chaperone
SCUBE2 signal peptide, CUB domain, EGF-like 2
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SPON1 spondin 1, extracellular matrix protein
SRSF2 serine/arginine-rich splicing factor 2
SST somatostatin
STAP2 signal transducing adaptor family member 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TIMP3 TIMP metallopeptidase inhibitor 3
TYRP1 tyrosinase-related protein 1