BRD-K33272502_DG-041_THP1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K33272502_DG-041_THP1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALB albumin
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCK cholecystokinin
CCNG2 cyclin G2
CD24 CD24 molecule
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
DAAM1 dishevelled associated activator of morphogenesis 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DST dystonin
EMX2 empty spiracles homeobox 2
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HYAL1 hyaluronoglucosaminidase 1
IFI27 interferon, alpha-inducible protein 27
ISYNA1 inositol-3-phosphate synthase 1
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLK5 kallikrein-related peptidase 5
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT8 keratin 8, type II
MAMLD1 mastermind-like domain containing 1
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NPIPB3 nuclear pore complex interacting protein family, member B3
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHIP pleckstrin homology domain interacting protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
STAMBP STAM binding protein
STXBP2 syntaxin binding protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TP63 tumor protein p63
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
ZNF451 zinc finger protein 451
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANKRD10 ankyrin repeat domain 10
BASP1 brain abundant, membrane attached signal protein 1
C14ORF169 chromosome 14 open reading frame 169
C1R complement component 1, r subcomponent
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CANT1 calcium activated nucleotidase 1
CCNE2 cyclin E2
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CERK ceramide kinase
CPVL carboxypeptidase, vitellogenic-like
CRELD2 cysteine-rich with EGF-like domains 2
CTSZ cathepsin Z
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DES desmin
ENO2 enolase 2 (gamma, neuronal)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD5 FXYD domain containing ion transport regulator 5
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRIA2 glutamate receptor, ionotropic, AMPA 2
HDAC1 histone deacetylase 1
HN1L hematological and neurological expressed 1-like
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
KANK2 KN motif and ankyrin repeat domains 2
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MED21 mediator complex subunit 21
MTERF3 mitochondrial transcription termination factor 3
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFA4 NDUFA4, mitochondrial complex associated
NT5DC2 5'-nucleotidase domain containing 2
PLIN3 perilipin 3
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCB protein kinase C, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
SEPW1 selenoprotein W, 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP11 THAP domain containing 11
TOB2 transducer of ERBB2, 2
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZBTB18 zinc finger and BTB domain containing 18