BRD-K33272502_DG-041_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K33272502_DG-041_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ANXA1 annexin A1
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BEX4 brain expressed, X-linked 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
COG5 component of oligomeric golgi complex 5
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NRGN neurogranin (protein kinase C substrate, RC3)
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMP22 peripheral myelin protein 22
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOSTDC1 sclerostin domain containing 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
DYNLL1 dynein, light chain, LC8-type 1
GNAS GNAS complex locus
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IRF8 interferon regulatory factor 8
KCTD12 potassium channel tetramerization domain containing 12
LAMP5 lysosomal-associated membrane protein family, member 5
LONP2 lon peptidase 2, peroxisomal
MFAP2 microfibrillar-associated protein 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NID2 nidogen 2 (osteonidogen)
NT5DC2 5'-nucleotidase domain containing 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDIA3 protein disulfide isomerase family A, member 3
POSTN periostin, osteoblast specific factor
QPRT quinolinate phosphoribosyltransferase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM97 transmembrane protein 97
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)