BRD-K33272502_DG-041_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

279 genes differentially expressed following the BRD-K33272502_DG-041_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C5ORF28 chromosome 5 open reading frame 28
CARS cysteinyl-tRNA synthetase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG2 cyclin G2
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GPR87 G protein-coupled receptor 87
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
JUP junction plakoglobin
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NOV nephroblastoma overexpressed
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PICALM phosphatidylinositol binding clathrin assembly protein
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PTHLH parathyroid hormone-like hormone
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAD23B RAD23 homolog B (S. cerevisiae)
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
RPL10 ribosomal protein L10
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SF1 splicing factor 1
SFN stratifin
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM135 transmembrane protein 135
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB1 transducer of ERBB2, 1
TP63 tumor protein p63
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
USP6NL USP6 N-terminal like
VCL vinculin
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
ZBTB10 zinc finger and BTB domain containing 10
ZBTB38 zinc finger and BTB domain containing 38
ZC3H15 zinc finger CCCH-type containing 15
ZEB2 zinc finger E-box binding homeobox 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF165 zinc finger protein 165
ZZZ3 zinc finger, ZZ-type containing 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASRGL1 asparaginase like 1
B3GNT1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCND3 cyclin D3
CCNF cyclin F
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CKLF chemokine-like factor
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
ECI2 enoyl-CoA delta isomerase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR4 fibroblast growth factor receptor 4
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP5 FK506 binding protein 5
FRZB frizzled-related protein
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GMFG glia maturation factor, gamma
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KLK11 kallikrein-related peptidase 11
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC17 leucine rich repeat containing 17
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
METTL9 methyltransferase like 9
MLEC malectin
MSRB1 methionine sulfoxide reductase B1
NELL2 NEL-like 2 (chicken)
NMT1 N-myristoyltransferase 1
NOTCH3 notch 3
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTDSS1 phosphatidylserine synthase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
RGS5 regulator of G-protein signaling 5
SAC3D1 SAC3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT8 septin 8
SIVA1 SIVA1, apoptosis-inducing factor
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC46A3 solute carrier family 46, member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STMN1 stathmin 1
TFDP1 transcription factor Dp-1
THAP11 THAP domain containing 11
TMEM106C transmembrane protein 106C
TMEM243 transmembrane protein 243, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TYROBP TYRO protein tyrosine kinase binding protein
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WFS1 Wolfram syndrome 1 (wolframin)
WIF1 WNT inhibitory factor 1