BRD-K33272502_DG-041_SW480_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K33272502_DG-041_SW480_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA1 high mobility group AT-hook 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PER1 period circadian clock 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SMNDC1 survival motor neuron domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
SYBU syntabulin (syntaxin-interacting)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
WBP5 WW domain binding protein 5
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
BST2 bone marrow stromal cell antigen 2
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDA cytidine deaminase
COL5A1 collagen, type V, alpha 1
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
DES desmin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDNRA endothelin receptor type A
ESR1 estrogen receptor 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GPX2 glutathione peroxidase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IRS1 insulin receptor substrate 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0355 KIAA0355
LAMA2 laminin, alpha 2
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LY86 lymphocyte antigen 86
MAP1B microtubule-associated protein 1B
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NELL2 NEL-like 2 (chicken)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PIP prolactin-induced protein
PLXNC1 plexin C1
PROM1 prominin 1
PSPH phosphoserine phosphatase
RABAC1 Rab acceptor 1 (prenylated)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RNF144A ring finger protein 144A
RPA3 replication protein A3, 14kDa
SEPT6 septin 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble