BRD-K33272502_DG-041_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K33272502_DG-041_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ANXA4 annexin A4
AQP8 aquaporin 8
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BMP4 bone morphogenetic protein 4
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP57 centrosomal protein 57kDa
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
COL9A3 collagen, type IX, alpha 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXF2 forkhead box F2
GARS glycyl-tRNA synthetase
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MYO1D myosin ID
NNMT nicotinamide N-methyltransferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAD21 RAD21 homolog (S. pombe)
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A6 solute carrier family 16, member 6
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPEN spen family transcriptional repressor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ARGLU1 arginine and glutamate rich 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
C14ORF1 chromosome 14 open reading frame 1
C16ORF45 chromosome 16 open reading frame 45
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO1A coronin, actin binding protein, 1A
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERI2 ERI1 exoribonuclease family member 2
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
JADE2 jade family PHD finger 2
LBR lamin B receptor
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMD monocyte to macrophage differentiation-associated
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NKG7 natural killer cell granule protein 7
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB15 RAB15, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
RPS26 ribosomal protein S26
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
STOM stomatin
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM164 transmembrane protein 164
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
ZDHHC6 zinc finger, DHHC-type containing 6