BRD-K33272502_DG-041_PL21_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K33272502_DG-041_PL21_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAA1 acetyl-CoA acyltransferase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CD69 CD69 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP70 centrosomal protein 70kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CTH cystathionine gamma-lyase
CYTIP cytohesin 1 interacting protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
ESRP1 epithelial splicing regulatory protein 1
FA2H fatty acid 2-hydroxylase
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPNMB glycoprotein (transmembrane) nmb
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MORC4 MORC family CW-type zinc finger 4
MX1 MX dynamin-like GTPase 1
NFASC neurofascin
NFIL3 nuclear factor, interleukin 3 regulated
NPR3 natriuretic peptide receptor 3
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
POU4F1 POU class 4 homeobox 1
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SH3BGR SH3 domain binding glutamate-rich protein
SH3BP4 SH3-domain binding protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TBC1D31 TBC1 domain family, member 31
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53 tumor protein p53
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP1 ubiquitin specific peptidase 1
VAMP4 vesicle-associated membrane protein 4
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZFAND1 zinc finger, AN1-type domain 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
COCH cochlin
CRIP2 cysteine-rich protein 2
DIO2 deiodinase, iodothyronine, type II
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP2 dual specificity phosphatase 2
EHD3 EH-domain containing 3
EXOSC4 exosome component 4
FHOD3 formin homology 2 domain containing 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSCN1 fascin actin-bundling protein 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
HACD3 3-hydroxyacyl-CoA dehydratase 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IPO7 importin 7
KLF10 Kruppel-like factor 10
LOC100505650 uncharacterized LOC100505650
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAT2A methionine adenosyltransferase II, alpha
MTA1 metastasis associated 1
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
NSG1 neuron specific gene family member 1
NT5DC2 5'-nucleotidase domain containing 2
OPN3 opsin 3
PEG10 paternally expressed 10
PNP purine nucleoside phosphorylase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMS spermine synthase
TMEM97 transmembrane protein 97
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa