BRD-K33272502_DG-041_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

375 genes differentially expressed following the BRD-K33272502_DG-041_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AHSP alpha hemoglobin stabilizing protein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHGB chromogranin B
CLCA4 chloride channel accessory 4
COPG1 coatomer protein complex, subunit gamma 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSG3 desmoglein 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN3 endothelin 3
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FKBP11 FK506 binding protein 11, 19 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IL1B interleukin 1, beta
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0226L KIAA0226-like
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
MAGED2 melanoma antigen family D2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MED8 mediator complex subunit 8
MGLL monoglyceride lipase
MICALL1 MICAL-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCOA3 nuclear receptor coactivator 3
NEU1 sialidase 1 (lysosomal sialidase)
NIT1 nitrilase 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAT1 phosphoserine aminotransferase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RAP1GAP RAP1 GTPase activating protein
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIOK3 RIO kinase 3
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SEC61G Sec61 gamma subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SRGN serglycin
SUCO SUN domain containing ossification factor
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TDO2 tryptophan 2,3-dioxygenase
TMEM39A transmembrane protein 39A
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA6 annexin A6
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKB aurora kinase B
B3GNT1
BAD BCL2-associated agonist of cell death
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C20ORF27 chromosome 20 open reading frame 27
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL4A2 collagen, type IV, alpha 2
COL6A3 collagen, type VI, alpha 3
CRYZ crystallin, zeta (quinone reductase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
ECI2 enoyl-CoA delta isomerase 2
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ELP5 elongator acetyltransferase complex subunit 5
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLO1 glyoxalase I
GMNN geminin, DNA replication inhibitor
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA10 homeobox A10
HOXB7 homeobox B7
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LMNB2 lamin B2
LTBP1 latent transforming growth factor beta binding protein 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOB monoamine oxidase B
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NASP nuclear autoantigenic sperm protein (histone-binding)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEBP1 phosphatidylethanolamine binding protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PSRC1 proline/serine-rich coiled-coil 1
PTMA prothymosin, alpha
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SULF1 sulfatase 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VCL vinculin
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZWINT ZW10 interacting kinetochore protein