BRD-K33272502_DG-041_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

313 genes differentially expressed following the BRD-K33272502_DG-041_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNG2 cyclin G2
CCNI cyclin I
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMX2 empty spiracles homeobox 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRB10 growth factor receptor-bound protein 10
GTF2IRD1 GTF2I repeat domain containing 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
MAN2A1 mannosidase, alpha, class 2A, member 1
MARS methionyl-tRNA synthetase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM1 PDZ and LIM domain 1
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB38 RAB38, member RAS oncogene family
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL1D1 ribosomal L1 domain containing 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SETD5 SET domain containing 5
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SQSTM1 sequestosome 1
SRI sorcin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
TTC17 tetratricopeptide repeat domain 17
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WSB1 WD repeat and SOCS box containing 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZBED2 zinc finger, BED-type containing 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF146 zinc finger protein 146
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKB aurora kinase B
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C7 complement component 7
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPM centromere protein M
CENPN centromere protein N
CETN2 centrin, EF-hand protein, 2
CMC2 C-x(9)-C motif containing 2
CRYZ crystallin, zeta (quinone reductase)
CYBA cytochrome b-245, alpha polypeptide
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DCTPP1 dCTP pyrophosphatase 1
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EMP2 epithelial membrane protein 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FBXO9 F-box protein 9
FEN1 flap structure-specific endonuclease 1
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPB11 heat shock protein family B (small), member 11
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPH non-SMC condensin I complex, subunit H
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PHB prohibitin
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PMPCA peptidase (mitochondrial processing) alpha
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNM synemin, intermediate filament protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2N ubiquitin-conjugating enzyme E2N
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein