BRD-K33272502_DG-041_HT29_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-K33272502_DG-041_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACVR1 activin A receptor, type I
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKAP4 cytoskeleton-associated protein 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CSTA cystatin A (stefin A)
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
IFRD1 interferon-related developmental regulator 1
INHBB inhibin, beta B
INHBE inhibin, beta E
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MB myoglobin
MIR22HG MIR22 host gene
MOCOS molybdenum cofactor sulfurase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
MYO15B myosin XVB
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
NMRK1 nicotinamide riboside kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEC63 SEC63 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CCNG1 cyclin G1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHEK2 checkpoint kinase 2
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM111A family with sequence similarity 111, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GATA2 GATA binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MREG melanoregulin
MSH6 mutS homolog 6
MYB v-myb avian myeloblastosis viral oncogene homolog
MYLK myosin light chain kinase
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NSL1 NSL1, MIS12 kinetochore complex component
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRKD3 protein kinase D3
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
QPRT quinolinate phosphoribosyltransferase
RAD51 RAD51 recombinase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBBP4 retinoblastoma binding protein 4
RFC2 replication factor C (activator 1) 2, 40kDa
RMI1 RecQ mediated genome instability 1
RPA3 replication protein A3, 14kDa
SEPT11 septin 11
SESN1 sestrin 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1