BRD-K33272502_DG-041_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K33272502_DG-041_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BGN biglycan
C3ORF14 chromosome 3 open reading frame 14
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUNB jun B proto-oncogene
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MARS methionyl-tRNA synthetase
MCOLN1 mucolipin 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAT plasminogen activator, tissue
PSAT1 phosphoserine aminotransferase 1
PTPRF protein tyrosine phosphatase, receptor type, F
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RB1CC1 RB1-inducible coiled-coil 1
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
STC2 stanniocalcin 2
SYNJ2 synaptojanin 2
TCEA1 transcription elongation factor A (SII), 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TREM1 triggering receptor expressed on myeloid cells 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANKRD10 ankyrin repeat domain 10
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL5 chemokine (C-C motif) ligand 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK6 cyclin-dependent kinase 6
CHI3L2 chitinase 3-like 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAIM Fas apoptotic inhibitory molecule
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GAL galanin/GMAP prepropeptide
HEBP1 heme binding protein 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
JMJD6 jumonji domain containing 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
MID1 midline 1
MMP7 matrix metallopeptidase 7
MXRA7 matrix-remodelling associated 7
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDZK1 PDZ domain containing 1
PIP prolactin-induced protein
PODXL podocalyxin-like
PSCA prostate stem cell antigen
REEP1 receptor accessory protein 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2