BRD-K33272502_DG-041_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

301 genes differentially expressed following the BRD-K33272502_DG-041_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP8L A kinase (PRKA) anchor protein 8-like
ANK2 ankyrin 2, neuronal
AREG amphiregulin
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CAPN6 calpain 6
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIPK1 homeodomain interacting protein kinase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL1A interleukin 1, alpha
IL6 interleukin 6
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LMNA lamin A/C
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MEX3C mex-3 RNA binding family member C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NANS N-acetylneuraminic acid synthase
NAV2 neuron navigator 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB2 nucleobindin 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SDF2L1 stromal cell-derived factor 2-like 1
SEC24A SEC24 family member A
SEC31A SEC31 homolog A (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TRIO trio Rho guanine nucleotide exchange factor
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BLCAP bladder cancer associated protein
C1QB complement component 1, q subcomponent, B chain
C1RL complement component 1, r subcomponent-like
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNF cyclin F
CD300A CD300a molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DOK4 docking protein 4
EMX2 empty spiracles homeobox 2
FANCL Fanconi anemia, complementation group L
FGFR2 fibroblast growth factor receptor 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX2 glutathione peroxidase 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HDAC1 histone deacetylase 1
HMGN3 high mobility group nucleosomal binding domain 3
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
INSM1 insulinoma-associated 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
MDK midkine (neurite growth-promoting factor 2)
NAP1L1 nucleosome assembly protein 1-like 1
NCAPD2 non-SMC condensin I complex, subunit D2
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
OLFM1 olfactomedin 1
PBX1 pre-B-cell leukemia homeobox 1
PERP PERP, TP53 apoptosis effector
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
RBP1 retinol binding protein 1, cellular
RNASET2 ribonuclease T2
RNF43 ring finger protein 43
RPA1 replication protein A1, 70kDa
RRM2 ribonucleotide reductase M2
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SOX11 SRY (sex determining region Y)-box 11
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
UNG uracil-DNA glycosylase
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta