BRD-K33272502_DG-041_A549_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K33272502_DG-041_A549_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL1A interleukin 1, alpha
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MMP1 matrix metallopeptidase 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
ASF1B anti-silencing function 1B histone chaperone
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP2 cysteine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EML4 echinoderm microtubule associated protein like 4
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HADH hydroxyacyl-CoA dehydrogenase
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF14 kinesin family member 14
LBH limb bud and heart development
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKSL1 MARCKS-like 1
MPHOSPH9 M-phase phosphoprotein 9
MYCBP MYC binding protein
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPY neuropeptide Y
NTS neurotensin
NUP210 nucleoporin 210kDa
PAWR PRKC, apoptosis, WT1, regulator
PCNA proliferating cell nuclear antigen
PHACTR2 phosphatase and actin regulator 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PTER phosphotriesterase related
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51C RAD51 paralog C
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
SEPHS1 selenophosphate synthetase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRA13 stimulated by retinoic acid 13
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPAN6 tetraspanin 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPK1B uroplakin 1B
VCAN versican