BRD-K33182644_2-[(3-methylphenyl)amino]-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one NCGC00071218-02_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K33182644_2-[(3-methylphenyl)amino]-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one NCGC00071218-02_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AREG amphiregulin
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CRABP1 cellular retinoic acid binding protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
DPT dermatopontin
DST dystonin
EMP1 epithelial membrane protein 1
FGFR2 fibroblast growth factor receptor 2
GAS1 growth arrest-specific 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT81 keratin 81, type II
MYO6 myosin VI
NES nestin
NFIB nuclear factor I/B
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SRGN serglycin
STK10 serine/threonine kinase 10
SYNM synemin, intermediate filament protein
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CST3 cystatin C
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DUSP1 dual specificity phosphatase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GRSF1 G-rich RNA sequence binding factor 1
GSTP1 glutathione S-transferase pi 1
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MSLN mesothelin
PSAP prosaposin
RUFY3 RUN and FYVE domain containing 3
SCO2 SCO2 cytochrome c oxidase assembly protein
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPEN spen family transcriptional repressor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCKL1 uridine-cytidine kinase 1-like 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VLDLR very low density lipoprotein receptor
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1