BRD-K33164466_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K33164466_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
AFF1 AF4/FMR2 family, member 1
AHNAK AHNAK nucleoprotein
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
C5ORF30 chromosome 5 open reading frame 30
CCND2 cyclin D2
CENPU centromere protein U
COL1A1 collagen, type I, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSV cathepsin V
ELOVL5 ELOVL fatty acid elongase 5
FASTKD5 FAST kinase domains 5
FLRT2 fibronectin leucine rich transmembrane protein 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCLC glutamate-cysteine ligase, catalytic subunit
GPATCH8 G patch domain containing 8
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQCG IQ motif containing G
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KYNU kynureninase
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MTSS1 metastasis suppressor 1
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NAV3 neuron navigator 3
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PLAC8 placenta-specific 8
PNISR PNN-interacting serine/arginine-rich protein
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RSRP1 arginine/serine-rich protein 1
RUFY3 RUN and FYVE domain containing 3
S100P S100 calcium binding protein P
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEC31A SEC31 homolog A (S. cerevisiae)
SELL selectin L
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMS spermine synthase
SORD sorbitol dehydrogenase
STK26 serine/threonine protein kinase 26
TARBP1 TAR (HIV-1) RNA binding protein 1
TNC tenascin C
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TXN thioredoxin
UBE2A ubiquitin-conjugating enzyme E2A
UFL1 UFM1-specific ligase 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
AKAP1 A kinase (PRKA) anchor protein 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
CD52 CD52 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
COL4A2 collagen, type IV, alpha 2
CRIP2 cysteine-rich protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTGF connective tissue growth factor
CTSD cathepsin D
CXCL6 chemokine (C-X-C motif) ligand 6
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FASN fatty acid synthase
FBP1 fructose-1,6-bisphosphatase 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FN1 fibronectin 1
GAA glucosidase, alpha; acid
HNMT histamine N-methyltransferase
HSPB1 heat shock 27kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
LAMP1 lysosomal-associated membrane protein 1
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NUCB1 nucleobindin 1
NUMA1 nuclear mitotic apparatus protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PLEC plectin
PRUNE2 prune homolog 2 (Drosophila)
PUF60 poly-U binding splicing factor 60KDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC2 replication factor C (activator 1) 2, 40kDa
RGCC regulator of cell cycle
RNH1 ribonuclease/angiogenin inhibitor 1
SAMD4A sterile alpha motif domain containing 4A
SDC2 syndecan 2
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRPR signal recognition particle receptor (docking protein)
STIP1 stress-induced phosphoprotein 1
STXBP2 syntaxin binding protein 2
TCL1A T-cell leukemia/lymphoma 1A
TEAD4 TEA domain family member 4
TGOLN2 trans-golgi network protein 2
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TMEM259 transmembrane protein 259
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF652 zinc finger protein 652
ZYX zyxin