BRD-K32292990_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K32292990_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATG3 autophagy related 3
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
COL10A1 collagen, type X, alpha 1
CPM carboxypeptidase M
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
EVI2A ecotropic viral integration site 2A
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAB2 GRB2-associated binding protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL4R interleukin 4 receptor
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NT5E 5'-nucleotidase, ecto (CD73)
PARP8 poly (ADP-ribose) polymerase family, member 8
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTX3 pentraxin 3, long
RSF1 remodeling and spacing factor 1
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
STAR steroidogenic acute regulatory protein
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TJP2 tight junction protein 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
B3GNT1
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C1S complement component 1, s subcomponent
CD99 CD99 molecule
CDC25B cell division cycle 25B
COL3A1 collagen, type III, alpha 1
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAM134B family with sequence similarity 134, member B
FGB fibrinogen beta chain
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAS2 growth arrest-specific 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GYG2 glycogenin 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IFI44 interferon-induced protein 44
ITM2A integral membrane protein 2A
LRRN3 leucine rich repeat neuronal 3
MCAM melanoma cell adhesion molecule
METTL3 methyltransferase like 3
MID1 midline 1
MSH6 mutS homolog 6
MTMR4 myotubularin related protein 4
NDRG3 NDRG family member 3
NUP62 nucleoporin 62kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP2 poly (ADP-ribose) polymerase 2
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
SALL2 spalt-like transcription factor 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX11 SRY (sex determining region Y)-box 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TMEM97 transmembrane protein 97
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)