BRD-K31912990_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K31912990_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXORF40B chromosome X open reading frame 40B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM171A1 family with sequence similarity 171, member A1
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
KCTD5 potassium channel tetramerization domain containing 5
KRT7 keratin 7, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MSLN mesothelin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PSME4 proteasome (prosome, macropain) activator subunit 4
PTX3 pentraxin 3, long
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBL1X transducin (beta)-like 1X-linked
TBL2 transducin (beta)-like 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TNIP1 TNFAIP3 interacting protein 1
TXNRD1 thioredoxin reductase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
B3GNT1
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CDC7 cell division cycle 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
COG2 component of oligomeric golgi complex 2
COX11 COX11 cytochrome c oxidase copper chaperone
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DSG2 desmoglein 2
FAM162A family with sequence similarity 162, member A
FZD4 frizzled class receptor 4
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPI glucose-6-phosphate isomerase
H3F3B H3 histone, family 3B (H3.3B)
HLTF helicase-like transcription factor
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IL17RB interleukin 17 receptor B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MXRA7 matrix-remodelling associated 7
PGAM1 phosphoglycerate mutase 1 (brain)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TRAPPC3 trafficking protein particle complex 3
TSPAN12 tetraspanin 12