BRD-K31342827_GF-109203X_NCIH2073_6.0_h_12.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K31342827_GF-109203X_NCIH2073_6.0_h_12.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADCY9 adenylate cyclase 9
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHSG alpha-2-HS-glycoprotein
ANKRD10 ankyrin repeat domain 10
APOA2 apolipoprotein A-II
ASRGL1 asparaginase like 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CCP110 centriolar coiled coil protein 110kDa
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP14 dual specificity phosphatase 14
DUSP7 dual specificity phosphatase 7
EBP emopamil binding protein (sterol isomerase)
ENO2 enolase 2 (gamma, neuronal)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLS glutaminase
GLUL glutamate-ammonia ligase
GPR88 G protein-coupled receptor 88
GPX4 glutathione peroxidase 4
H1F0 H1 histone family, member 0
HDAC9 histone deacetylase 9
HIST3H2A histone cluster 3, H2a
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
KLK11 kallikrein-related peptidase 11
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MCAM melanoma cell adhesion molecule
MSMO1 methylsterol monooxygenase 1
MUC4 mucin 4, cell surface associated
NMU neuromedin U
NOV nephroblastoma overexpressed
PANK3 pantothenate kinase 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PENK proenkephalin
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA1 paraneoplastic Ma antigen 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXMP2 peroxisomal membrane protein 2, 22kDa
RHOQ ras homolog family member Q
RSL1D1 ribosomal L1 domain containing 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCRN1 secernin 1
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM97 transmembrane protein 97
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
ZMAT3 zinc finger, matrin-type 3
ZNF330 zinc finger protein 330

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
C3ORF14 chromosome 3 open reading frame 14
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLC Charcot-Leyden crystal galectin
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL4A5 collagen, type IV, alpha 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FSTL1 follistatin-like 1
GPR171 G protein-coupled receptor 171
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
ITK IL2-inducible T-cell kinase
LAMB1 laminin, beta 1
LXN latexin
MET MET proto-oncogene, receptor tyrosine kinase
MYO10 myosin X
NCALD neurocalcin delta
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX1 neuronal pentraxin I
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PLS3 plastin 3
PON2 paraoxonase 2
PTCH1 patched 1
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
STAMBP STAM binding protein
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE3C ubiquitin protein ligase E3C
VAMP8 vesicle-associated membrane protein 8
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF586 zinc finger protein 586