BRD-K30849099_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K30849099_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
CBS cystathionine-beta-synthase
CHGB chromogranin B
CYTIP cytohesin 1 interacting protein
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
GAGE3 G antigen 3
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIC2 hypermethylated in cancer 2
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
MFSD12 major facilitator superfamily domain containing 12
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
PTPRC protein tyrosine phosphatase, receptor type, C
RTN1 reticulon 1
SCG5 secretogranin V
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DLD dihydrolipoamide dehydrogenase
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HLTF helicase-like transcription factor
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
KAT6B K(lysine) acetyltransferase 6B
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LUM lumican
LXN latexin
MARCKSL1 MARCKS-like 1
MBP myelin basic protein
MET MET proto-oncogene, receptor tyrosine kinase
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
PCNA proliferating cell nuclear antigen
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TMEM47 transmembrane protein 47
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C