BRD-K30849099_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K30849099_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHSG alpha-2-HS-glycoprotein
ANXA3 annexin A3
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFB complement factor B
COL9A2 collagen, type IX, alpha 2
CPE carboxypeptidase E
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYCS cytochrome c, somatic
DNM1L dynamin 1-like
DST dystonin
EBNA1BP2 EBNA1 binding protein 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GMPR guanosine monophosphate reductase
GPRC5B G protein-coupled receptor, class C, group 5, member B
HDAC9 histone deacetylase 9
HIC2 hypermethylated in cancer 2
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFRD2 interferon-related developmental regulator 2
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
MMP10 matrix metallopeptidase 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLXNA1 plexin A1
PODXL podocalyxin-like
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRPF4 pre-mRNA processing factor 4
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SAMD4A sterile alpha motif domain containing 4A
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SQLE squalene epoxidase
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRPS1 trichorhinophalangeal syndrome I
TYRP1 tyrosinase-related protein 1
USP1 ubiquitin specific peptidase 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BACE2 beta-site APP-cleaving enzyme 2
C8ORF4 chromosome 8 open reading frame 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAPK1 death-associated protein kinase 1
DSE dermatan sulfate epimerase
ECHDC2 enoyl CoA hydratase domain containing 2
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FGFR4 fibroblast growth factor receptor 4
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HAPLN1 hyaluronan and proteoglycan link protein 1
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAM3 junctional adhesion molecule 3
KLHL9 kelch-like family member 9
LAMB1 laminin, beta 1
LXN latexin
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP11 matrix metallopeptidase 11
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
OLFML2A olfactomedin-like 2A
PDIA3 protein disulfide isomerase family A, member 3
PGD phosphogluconate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON3 paraoxonase 3
PPA2 pyrophosphatase (inorganic) 2
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL36 ribosomal protein L36
RPL38 ribosomal protein L38
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SFRP4 secreted frizzled-related protein 4
SLC16A4 solute carrier family 16, member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
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