BRD-K30707190_PNU 74654_PC3_24.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K30707190_PNU 74654_PC3_24.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALAS1 5'-aminolevulinate synthase 1
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL9A2 collagen, type IX, alpha 2
CRISP3 cysteine-rich secretory protein 3
CSNK1E casein kinase 1, epsilon
CXCL3 chemokine (C-X-C motif) ligand 3
DAAM2 dishevelled associated activator of morphogenesis 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EZR ezrin
FBN2 fibrillin 2
FSTL1 follistatin-like 1
FZD5 frizzled class receptor 5
GARS glycyl-tRNA synthetase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL7R interleukin 7 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MGLL monoglyceride lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP1 matrix metallopeptidase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH9 myosin, heavy chain 9, non-muscle
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPARD peroxisome proliferator-activated receptor delta
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLAMF7 SLAM family member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SRGN serglycin
STC2 stanniocalcin 2
TOX3 TOX high mobility group box family member 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WIF1 WNT inhibitory factor 1
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CLU clusterin
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ETV1 ets variant 1
EXOSC4 exosome component 4
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IGF1 insulin-like growth factor 1 (somatomedin C)
KIAA0101 KIAA0101
KIAA0922 KIAA0922
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
MAOB monoamine oxidase B
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MPO myeloperoxidase
MRPL3 mitochondrial ribosomal protein L3
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
PAIP1 poly(A) binding protein interacting protein 1
PCNA proliferating cell nuclear antigen
PPIF peptidylprolyl isomerase F
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD1 SMAD family member 1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SVIL supervillin
TM2D3 TM2 domain containing 3
TM4SF1 transmembrane 4 L six family member 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
UNG uracil-DNA glycosylase