BRD-K29395450_PIK-93_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

309 genes differentially expressed following the BRD-K29395450_PIK-93_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ARHGAP32 Rho GTPase activating protein 32
ASPH aspartate beta-hydroxylase
BAALC brain and acute leukemia, cytoplasmic
BCL2L1 BCL2-like 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1QTNF3 C1q and tumor necrosis factor related protein 3
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN4 claudin 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK9 dedicator of cytokinesis 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDUA iduronidase, alpha-L-
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0430 KIAA0430
KIAA1033 KIAA1033
KLHDC2 kelch domain containing 2
KYNU kynureninase
LAMB1 laminin, beta 1
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MLPH melanophilin
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NCK2 NCK adaptor protein 2
NCOA3 nuclear receptor coactivator 3
NPAS2 neuronal PAS domain protein 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PHF20 PHD finger protein 20
PI3 peptidase inhibitor 3, skin-derived
PLAGL1 pleiomorphic adenoma gene-like 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
PRSS8 protease, serine, 8
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RBM25 RNA binding motif protein 25
RBM47 RNA binding motif protein 47
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHCG Rh family, C glycoprotein
RND3 Rho family GTPase 3
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A6 solute carrier family 16, member 6
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPX sushi-repeat containing protein, X-linked
SSPN sarcospan
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS3 thrombospondin 3
TMC5 transmembrane channel-like 5
TMEM5 transmembrane protein 5
TMEM63A transmembrane protein 63A
TMPRSS3 transmembrane protease, serine 3
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TTC17 tetratricopeptide repeat domain 17
TWIST1 twist family bHLH transcription factor 1
UBXN4 UBX domain protein 4
UPK3B uroplakin 3B
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIPF3 Yip1 domain family, member 3
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATAD2 ATPase family, AAA domain containing 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CRYAB crystallin, alpha B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL9 chemokine (C-X-C motif) ligand 9
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM1L dynamin 1-like
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGFR epidermal growth factor receptor
ENO1 enolase 1, (alpha)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM64A family with sequence similarity 64, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLF hepatic leukemia factor
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGN2 high mobility group nucleosomal binding domain 2
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LAGE3 L antigen family, member 3
LAPTM5 lysosomal protein transmembrane 5
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAOB monoamine oxidase B
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAM1 neural cell adhesion molecule 1
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NID1 nidogen 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PLS1 plastin 1
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOR3A torsin family 3, member A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRMT5 tRNA methyltransferase 5
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein