BRD-K29395450_PIK-93_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K29395450_PIK-93_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANOS1 anosmin 1
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCAM basal cell adhesion molecule (Lutheran blood group)
C6ORF48 chromosome 6 open reading frame 48
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPN3 calpain 3, (p94)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNPY3 canopy FGF signaling regulator 3
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV1 ets variant 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GAS6 growth arrest-specific 6
GPATCH8 G patch domain containing 8
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
HIST1H2AC histone cluster 1, H2ac
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT19 keratin 19, type I
KYNU kynureninase
LAMA3 laminin, alpha 3
LEPR leptin receptor
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MLPH melanophilin
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNB1 cyclin B1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPI centromere protein I
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DNM1L dynamin 1-like
FADS2 fatty acid desaturase 2
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HIC2 hypermethylated in cancer 2
HK2 hexokinase 2
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB6 homeobox B6
INSIG1 insulin induced gene 1
KIF23 kinesin family member 23
KLF4 Kruppel-like factor 4 (gut)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MEX3D mex-3 RNA binding family member D
MFSD12 major facilitator superfamily domain containing 12
MKI67 marker of proliferation Ki-67
MME membrane metallo-endopeptidase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
RGS1 regulator of G-protein signaling 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SPP1 secreted phosphoprotein 1
TKTL1 transketolase-like 1
UBE2S ubiquitin-conjugating enzyme E2S
WHSC1 Wolf-Hirschhorn syndrome candidate 1