BRD-K29395450_PIK-93_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K29395450_PIK-93_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
BLVRB biliverdin reductase B
C1RL complement component 1, r subcomponent-like
C8ORF4 chromosome 8 open reading frame 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
DHRS3 dehydrogenase/reductase (SDR family) member 3
FABP4 fatty acid binding protein 4, adipocyte
FAXDC2 fatty acid hydroxylase domain containing 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GPX3 glutathione peroxidase 3
JUP junction plakoglobin
LXN latexin
MAGED2 melanoma antigen family D2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MXI1 MAX interactor 1, dimerization protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGLS 6-phosphogluconolactonase
PLSCR4 phospholipid scramblase 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPOX protoporphyrinogen oxidase
RALGDS ral guanine nucleotide dissociation stimulator
RSRP1 arginine/serine-rich protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC38A2 solute carrier family 38, member 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STXBP2 syntaxin binding protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
ANPEP alanyl (membrane) aminopeptidase
ATAD2 ATPase family, AAA domain containing 2
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
HMGB2 high mobility group box 2
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
PFN2 profilin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa