BRD-K29395450_PIK-93_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K29395450_PIK-93_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCK3 aarF domain containing kinase 3
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ARID4B AT rich interactive domain 4B (RBP1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
BRD8 bromodomain containing 8
CA12 carbonic anhydrase XII
CD320 CD320 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFD complement factor D (adipsin)
CHGB chromogranin B
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTSE cathepsin E
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FBXL12 F-box and leucine-rich repeat protein 12
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
HBP1 HMG-box transcription factor 1
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
INSM1 insulinoma-associated 1
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LMOD1 leiomodin 1 (smooth muscle)
MEG3 maternally expressed 3 (non-protein coding)
MLPH melanophilin
MX1 MX dynamin-like GTPase 1
MYLK myosin light chain kinase
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RBPMS RNA binding protein with multiple splicing
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SNAP25 synaptosomal-associated protein, 25kDa
SORBS3 sorbin and SH3 domain containing 3
SPAG4 sperm associated antigen 4
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ANXA3 annexin A3
ASRGL1 asparaginase like 1
BAG3 BCL2-associated athanogene 3
CCND1 cyclin D1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CLGN calmegin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM198B family with sequence similarity 198, member B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOLR1 folate receptor 1 (adult)
GAGE3 G antigen 3
GATA2 GATA binding protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IL32 interleukin 32
KIAA1598
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LEPROTL1 leptin receptor overlapping transcript-like 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYRM1 LYR motif containing 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MINA MYC induced nuclear antigen
MMP9 matrix metallopeptidase 9
NKX3-1 NK3 homeobox 1
ODC1 ornithine decarboxylase 1
PI3 peptidase inhibitor 3, skin-derived
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT6 septin 6
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRR1B small proline-rich protein 1B
TAL1 T-cell acute lymphocytic leukemia 1
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TMC5 transmembrane channel-like 5
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1