BRD-K29395450_PIK-93_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K29395450_PIK-93_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ATF4 activating transcription factor 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CCNI cyclin I
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM102A family with sequence similarity 102, member A
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GTPBP8 GTP-binding protein 8 (putative)
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
ITGB5 integrin, beta 5
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LETMD1 LETM1 domain containing 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MSLN mesothelin
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OSBPL1A oxysterol binding protein-like 1A
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC11A SEC11 homolog A (S. cerevisiae)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SNX1 sorting nexin 1
SPATA20 spermatogenesis associated 20
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TOB1 transducer of ERBB2, 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
DHCR7 7-dehydrocholesterol reductase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HELLS helicase, lymphoid-specific
HOXA10 homeobox A10
KCTD12 potassium channel tetramerization domain containing 12
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
PBK PDZ binding kinase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRPF4 pre-mRNA processing factor 4
PTHLH parathyroid hormone-like hormone
RAD51C RAD51 paralog C
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
TFRC transferrin receptor
TMPO thymopoietin
TOR3A torsin family 3, member A
TUBB6 tubulin, beta 6 class V
UCK2 uridine-cytidine kinase 2
ZWINT ZW10 interacting kinetochore protein