BRD-K29395450_PIK-93_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K29395450_PIK-93_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AHNAK2 AHNAK nucleoprotein 2
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN7 claudin 7
COL21A1 collagen, type XXI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBLN1 fibulin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GSTZ1 glutathione S-transferase zeta 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IL15 interleukin 15
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PGLS 6-phosphogluconolactonase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRUNE2 prune homolog 2 (Drosophila)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SMAD3 SMAD family member 3
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TSC22D3 TSC22 domain family, member 3
TSPO translocator protein (18kDa)
TST thiosulfate sulfurtransferase (rhodanese)

decreased expression

Symbol Name
ATF5 activating transcription factor 5
ATP13A3 ATPase type 13A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLMH bleomycin hydrolase
C3 complement component 3
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHPT1 choline phosphotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
ELF5 E74-like factor 5 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP7 fatty acid binding protein 7, brain
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MAGEB2 melanoma antigen family B2
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MMP7 matrix metallopeptidase 7
PEG3 paternally expressed 3
PFN2 profilin 2
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
PTX3 pentraxin 3, long
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SQLE squalene epoxidase
TF transferrin
TFAM transcription factor A, mitochondrial
TMEM158 transmembrane protein 158 (gene/pseudogene)
XIST X inactive specific transcript (non-protein coding)