BRD-K29395450_PIK-93_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K29395450_PIK-93_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT1 angiopoietin 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP9A ATPase, class II, type 9A
AZIN1 antizyme inhibitor 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CD47 CD47 molecule
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EDN1 endothelin 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
HLA-E major histocompatibility complex, class I, E
IFI44L interferon-induced protein 44-like
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LTBP2 latent transforming growth factor beta binding protein 2
MEIS1 Meis homeobox 1
MLPH melanophilin
MVP major vault protein
NEBL nebulette
NPDC1 neural proliferation, differentiation and control, 1
NRCAM neuronal cell adhesion molecule
PLSCR4 phospholipid scramblase 4
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTPRK protein tyrosine phosphatase, receptor type, K
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
REEP1 receptor accessory protein 1
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN2 stathmin 2
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPO translocator protein (18kDa)
UFM1 ubiquitin-fold modifier 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ANO1 anoctamin 1, calcium activated chloride channel
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNASE1L3 deoxyribonuclease I-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FPGS folylpolyglutamate synthase
FXYD6 FXYD domain containing ion transport regulator 6
FZD5 frizzled class receptor 5
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP5 insulin-like growth factor binding protein 5
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NMU neuromedin U
OIP5 Opa interacting protein 5
OLFML2B olfactomedin-like 2B
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSRC1 proline/serine-rich coiled-coil 1
RRM2 ribonucleotide reductase M2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
STAR steroidogenic acute regulatory protein
TDO2 tryptophan 2,3-dioxygenase
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein