BRD-K29395450_PIK-93_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K29395450_PIK-93_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADD3 adducin 3 (gamma)
AFF1 AF4/FMR2 family, member 1
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BPGM 2,3-bisphosphoglycerate mutase
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
CCND1 cyclin D1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD59 CD59 molecule, complement regulatory protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP8 dipeptidyl-peptidase 8
DUSP22 dual specificity phosphatase 22
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FAM8A1 family with sequence similarity 8, member A1
FBN1 fibrillin 1
FOXO4 forkhead box O4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGB1 golgin B1
GPC3 glypican 3
GSN gelsolin
HBP1 HMG-box transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
IDS iduronate 2-sulfatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2A integral membrane protein 2A
JAM3 junctional adhesion molecule 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LPIN1 lipin 1
LTBP3 latent transforming growth factor beta binding protein 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MT1F metallothionein 1F
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NEBL nebulette
NKTR natural killer cell triggering receptor
NMRK1 nicotinamide riboside kinase 1
NOVA1 neuro-oncological ventral antigen 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
OXTR oxytocin receptor
PCDH9 protocadherin 9
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PINK1 PTEN induced putative kinase 1
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PROS1 protein S (alpha)
PSD3 pleckstrin and Sec7 domain containing 3
RABAC1 Rab acceptor 1 (prenylated)
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SRPX2 sushi-repeat containing protein, X-linked 2
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TRPS1 trichorhinophalangeal syndrome I
TSPAN5 tetraspanin 5
TTC3 tetratricopeptide repeat domain 3
VEGFC vascular endothelial growth factor C
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP5 acid phosphatase 5, tartrate resistant
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AQP3 aquaporin 3 (Gill blood group)
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLVRA biliverdin reductase A
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CKB creatine kinase, brain
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EHF ets homologous factor
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FBXO21 F-box protein 21
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IGHM immunoglobulin heavy constant mu
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS1 regulator of G-protein signaling 1
RNH1 ribonuclease/angiogenin inhibitor 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SGK1 serum/glucocorticoid regulated kinase 1
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
ZWINT ZW10 interacting kinetochore protein