BRD-K29395450_PIK-93_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K29395450_PIK-93_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AFF1 AF4/FMR2 family, member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMACR alpha-methylacyl-CoA racemase
APOM apolipoprotein M
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1RL complement component 1, r subcomponent-like
C21ORF33 chromosome 21 open reading frame 33
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD44 CD44 molecule (Indian blood group)
CIDEB cell death-inducing DFFA-like effector b
CP ceruloplasmin (ferroxidase)
CPT1A carnitine palmitoyltransferase 1A (liver)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSA cathepsin A
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM13A family with sequence similarity 13, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLS glutaminase
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GSTZ1 glutathione S-transferase zeta 1
HGD homogentisate 1,2-dioxygenase
HIST1H2AC histone cluster 1, H2ac
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP1 insulin-like growth factor binding protein 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT81 keratin 81, type II
LEPR leptin receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LRP5 low density lipoprotein receptor-related protein 5
LTBP3 latent transforming growth factor beta binding protein 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MGLL monoglyceride lipase
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLSCR4 phospholipid scramblase 4
PPAP2B phosphatidic acid phosphatase type 2B
PRKCA protein kinase C, alpha
RAB40B RAB40B, member RAS oncogene family
SLC22A18 solute carrier family 22, member 18
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TST thiosulfate sulfurtransferase (rhodanese)
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
DBF4 DBF4 zinc finger
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MEIS2 Meis homeobox 2
MEX3D mex-3 RNA binding family member D
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
OASL 2'-5'-oligoadenylate synthetase-like
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PTPRK protein tyrosine phosphatase, receptor type, K
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)