BRD-K29395450_PIK-93_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K29395450_PIK-93_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
ENDOD1 endonuclease domain containing 1
FAM63A family with sequence similarity 63, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD2 FXYD domain containing ion transport regulator 2
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HOXC10 homeobox C10
HOXC6 homeobox C6
IGFBP6 insulin-like growth factor binding protein 6
LRMP lymphoid-restricted membrane protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
PNMA2 paraneoplastic Ma antigen 2
PRSS3 protease, serine, 3
RAB4A RAB4A, member RAS oncogene family
RIPK4 receptor-interacting serine-threonine kinase 4
RPS4Y1 ribosomal protein S4, Y-linked 1
SCPEP1 serine carboxypeptidase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STX1A syntaxin 1A (brain)
TESC tescalcin
TMPRSS3 transmembrane protease, serine 3
TMX4 thioredoxin-related transmembrane protein 4
TSPAN8 tetraspanin 8
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AEBP1 AE binding protein 1
ARHGAP5 Rho GTPase activating protein 5
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
C3 complement component 3
CBR3 carbonyl reductase 3
CCP110 centriolar coiled coil protein 110kDa
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
EAPP E2F-associated phosphoprotein
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
GATA2 GATA binding protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
LAP3 leucine aminopeptidase 3
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MYH10 myosin, heavy chain 10, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
NLRP2 NLR family, pyrin domain containing 2
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PLXNC1 plexin C1
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRD protein tyrosine phosphatase, receptor type, D
PUS7 pseudouridylate synthase 7 (putative)
RGS2 regulator of G-protein signaling 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPON1 spondin 1, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SULF1 sulfatase 1
TBX3 T-box 3
TCF4 transcription factor 4
TF transferrin
THBS1 thrombospondin 1
TRPS1 trichorhinophalangeal syndrome I
TXNDC9 thioredoxin domain containing 9