BRD-K29395450_PIK-93_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K29395450_PIK-93_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACACB acetyl-CoA carboxylase beta
ADRB2 adrenoceptor beta 2, surface
ARL4C ADP-ribosylation factor-like 4C
BCHE butyrylcholinesterase
BRD8 bromodomain containing 8
BTN3A2 butyrophilin, subfamily 3, member A2
CALHM2 calcium homeostasis modulator 2
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD99 CD99 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CFD complement factor D (adipsin)
CLEC3B C-type lectin domain family 3, member B
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DHFR dihydrofolate reductase
DMBT1 deleted in malignant brain tumors 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GSTZ1 glutathione S-transferase zeta 1
HOPX HOP homeobox
HOXA5 homeobox A5
IFI16 interferon, gamma-inducible protein 16
IL2RB interleukin 2 receptor, beta
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
LDB2 LIM domain binding 2
LHFP lipoma HMGIC fusion partner
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
N4BP2L1 NEDD4 binding protein 2-like 1
NELL2 NEL-like 2 (chicken)
NUSAP1 nucleolar and spindle associated protein 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RAB13 RAB13, member RAS oncogene family
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TCEA2 transcription elongation factor A (SII), 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TSC22D1 TSC22 domain family, member 1
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHD7 chromodomain helicase DNA binding protein 7
CLDN8 claudin 8
COL9A3 collagen, type IX, alpha 3
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EGF epidermal growth factor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP14 FK506 binding protein 14, 22 kDa
GLS glutaminase
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
KRT23 keratin 23, type I
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
LYZ lysozyme
MCAM melanoma cell adhesion molecule
MMP10 matrix metallopeptidase 10
NES nestin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PDLIM4 PDZ and LIM domain 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
SATB1 SATB homeobox 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQLE squalene epoxidase
STC2 stanniocalcin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa