BRD-K29395450_PIK-93_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K29395450_PIK-93_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT1 angiopoietin 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ATP9A ATPase, class II, type 9A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL3 B-cell CLL/lymphoma 3
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CNPY3 canopy FGF signaling regulator 3
COL5A2 collagen, type V, alpha 2
CRISP3 cysteine-rich secretory protein 3
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CST1 cystatin SN
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DGKA diacylglycerol kinase, alpha 80kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETV1 ets variant 1
EVL Enah/Vasp-like
FBLN1 fibulin 1
FBN2 fibrillin 2
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX4 glutathione peroxidase 4
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0907 KIAA0907
KYNU kynureninase
LAMA3 laminin, alpha 3
LETMD1 LETM1 domain containing 1
LIMCH1 LIM and calponin homology domains 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCUR1 mitochondrial calcium uniporter regulator 1
MLPH melanophilin
MMP2 matrix metallopeptidase 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NGRN neugrin, neurite outgrowth associated
NTS neurotensin
PDE4DIP phosphodiesterase 4D interacting protein
PNISR PNN-interacting serine/arginine-rich protein
PPAP2C phosphatidic acid phosphatase type 2C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSRP1 arginine/serine-rich protein 1
SEPT10 septin 10
SFTPA2 surfactant protein A2
SKAP2 src kinase associated phosphoprotein 2
SPATA20 spermatogenesis associated 20
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
YBX3 Y box binding protein 3
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALB albumin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
BCHE butyrylcholinesterase
BHMT2 betaine--homocysteine S-methyltransferase 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC4 chloride intracellular channel 4
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENO1 enolase 1, (alpha)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F12 coagulation factor XII (Hageman factor)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GYG1 glycogenin 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT14 keratin 14, type I
LOC100505650 uncharacterized LOC100505650
MAOB monoamine oxidase B
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PCCB propionyl CoA carboxylase, beta polypeptide
PDE8B phosphodiesterase 8B
PDLIM4 PDZ and LIM domain 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PELI1 pellino E3 ubiquitin protein ligase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
STK17A serine/threonine kinase 17a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
WT1 Wilms tumor 1