BRD-K29395450_PIK-93_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K29395450_PIK-93_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP9A ATPase, class II, type 9A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CSRP2 cysteine and glycine-rich protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
LIMCH1 LIM and calponin homology domains 1
MAOA monoamine oxidase A
MOAP1 modulator of apoptosis 1
MZT2A mitotic spindle organizing protein 2A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHYH phytanoyl-CoA 2-hydroxylase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB13 RAB13, member RAS oncogene family
RNF167 ring finger protein 167
SEPP1 selenoprotein P, plasma, 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
WBP5 WW domain binding protein 5
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDN1 endothelin 1
EGF epidermal growth factor
EHD1 EH-domain containing 1
ELN elastin
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KAZN kazrin, periplakin interacting protein
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LCN2 lipocalin 2
LTF lactotransferrin
LYZ lysozyme
MINA MYC induced nuclear antigen
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
MYO1B myosin IB
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ORM1 orosomucoid 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
PRKCH protein kinase C, eta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
STK10 serine/threonine kinase 10
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZYX zyxin