BRD-K29395450_PIK-93_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K29395450_PIK-93_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP32 Rho GTPase activating protein 32
BACE2 beta-site APP-cleaving enzyme 2
BEX1 brain expressed, X-linked 1
CDK19 cyclin-dependent kinase 19
CEMIP cell migration inducing protein, hyaluronan binding
CXCL12 chemokine (C-X-C motif) ligand 12
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GBP2 guanylate binding protein 2, interferon-inducible
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LMO2 LIM domain only 2 (rhombotin-like 1)
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NBR1 neighbor of BRCA1 gene 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLSCR4 phospholipid scramblase 4
PRKCH protein kinase C, eta
PTGES prostaglandin E synthase
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CDC6 cell division cycle 6
CSE1L CSE1 chromosome segregation 1-like (yeast)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEFB1 defensin, beta 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRPL12 mitochondrial ribosomal protein L12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PNP purine nucleoside phosphorylase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RANBP1 RAN binding protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRM1 ribonucleotide reductase M1
S100A9 S100 calcium binding protein A9
SEPT9 septin 9
SFN stratifin
SLC43A3 solute carrier family 43, member 3
TAGLN2 transgelin 2
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TYMS thymidylate synthetase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta