BRD-K29395450_PIK-93_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K29395450_PIK-93_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
AREG amphiregulin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C16ORF45 chromosome 16 open reading frame 45
C1RL complement component 1, r subcomponent-like
C6ORF62 chromosome 6 open reading frame 62
CA11 carbonic anhydrase XI
CAV2 caveolin 2
CCPG1 cell cycle progression 1
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CST3 cystatin C
CTSO cathepsin O
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH8 G patch domain containing 8
GPX4 glutathione peroxidase 4
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI44L interferon-induced protein 44-like
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MTMR11 myotubularin related protein 11
MYLIP myosin regulatory light chain interacting protein
NAMPT nicotinamide phosphoribosyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PDGFD platelet derived growth factor D
PERP PERP, TP53 apoptosis effector
PHYH phytanoyl-CoA 2-hydroxylase
PNRC1 proline-rich nuclear receptor coactivator 1
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RNASE4 ribonuclease, RNase A family, 4
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A2 solute carrier family 38, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SPATA20 spermatogenesis associated 20
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SSPN sarcospan
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
TPCN1 two pore segment channel 1
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADRB2 adrenoceptor beta 2, surface
ALDOB aldolase B, fructose-bisphosphate
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AXIN1 axin 1
BARD1 BRCA1 associated RING domain 1
CALML3 calmodulin-like 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL4A2 collagen, type IV, alpha 2
CSTA cystatin A (stefin A)
DBF4 DBF4 zinc finger
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXO1 exonuclease 1
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAPG non-SMC condensin I complex, subunit G
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NEFL neurofilament, light polypeptide
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RHCG Rh family, C glycoprotein
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SPRR1A small proline-rich protein 1A
TARP TCR gamma alternate reading frame protein
TEX10 testis expressed 10
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TRIM14 tripartite motif containing 14
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein