BRD-K29395450_PIK-93_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

221 genes differentially expressed following the BRD-K29395450_PIK-93_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKAP8 A kinase (PRKA) anchor protein 8
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA4 annexin A4
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHRDL1 chordin-like 1
COL11A1 collagen, type XI, alpha 1
CPQ carboxypeptidase Q
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSNK1A1 casein kinase 1, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF5 eukaryotic translation initiation factor 5
ERP29 endoplasmic reticulum protein 29
FAXDC2 fatty acid hydroxylase domain containing 2
GBP2 guanylate binding protein 2, interferon-inducible
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GREM1 gremlin 1, DAN family BMP antagonist
GSAP gamma-secretase activating protein
GSDMB gasdermin B
HIST1H2AC histone cluster 1, H2ac
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOOK2 hook microtubule-tethering protein 2
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGHMBP2 immunoglobulin mu binding protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0907 KIAA0907
KYNU kynureninase
LDLR low density lipoprotein receptor
LETMD1 LETM1 domain containing 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100272216 uncharacterized LOC100272216
LOC399491
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MAPK13 mitogen-activated protein kinase 13
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MSLN mesothelin
MTMR11 myotubularin related protein 11
MVP major vault protein
MZF1 myeloid zinc finger 1
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NARFL nuclear prelamin A recognition factor-like
NDFIP1 Nedd4 family interacting protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDH9 protocadherin 9
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRUNE2 prune homolog 2 (Drosophila)
PSPC1 paraspeckle component 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS3 thrombospondin 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMED3 transmembrane emp24 protein transport domain containing 3
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1A anti-silencing function 1A histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CLU clusterin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSTA cystatin A (stefin A)
CTSG cathepsin G
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
FERMT2 fermitin family member 2
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
KIAA0101 KIAA0101
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
NXT1 nuclear transport factor 2-like export factor 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFN2 profilin 2
PLK4 polo-like kinase 4
PODXL podocalyxin-like
PRDX2 peroxiredoxin 2
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1A small proline-rich protein 1A
SRGN serglycin
STMN1 stathmin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TJP2 tight junction protein 2
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
ZWINT ZW10 interacting kinetochore protein