BRD-K28916077_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K28916077_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ANGPT2 angiopoietin 2
ANOS1 anosmin 1
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL13A1 collagen, type XIII, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPHB2 EPH receptor B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FCGBP Fc fragment of IgG binding protein
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBEGF heparin-binding EGF-like growth factor
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPSE heparanase
ICAM2 intercellular adhesion molecule 2
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IRF1 interferon regulatory factor 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
NAV2 neuron navigator 2
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
STS steroid sulfatase (microsomal), isozyme S
TCEAL2 transcription elongation factor A (SII)-like 2
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRG6 adhesion G protein-coupled receptor G6
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRA2A adrenoceptor alpha 2A
AKAP7 A kinase (PRKA) anchor protein 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATXN1 ataxin 1
BASP1 brain abundant, membrane attached signal protein 1
C2CD2 C2 calcium-dependent domain containing 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSG cathepsin G
DCK deoxycytidine kinase
DCP2 decapping mRNA 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
HOXC10 homeobox C10
HOXC6 homeobox C6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LAMP1 lysosomal-associated membrane protein 1
LIMCH1 LIM and calponin homology domains 1
LYST lysosomal trafficking regulator
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MGP matrix Gla protein
MX2 MX dynamin-like GTPase 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASET2 ribonuclease T2
RPS26 ribosomal protein S26
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAND1 SCAN domain containing 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3YL1 SH3 and SYLF domain containing 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TMED2 transmembrane emp24 domain trafficking protein 2
TOR1AIP1 torsin A interacting protein 1
TPX2 TPX2, microtubule-associated
UGCG UDP-glucose ceramide glucosyltransferase
ZNF586 zinc finger protein 586