BRD-K28452084_N-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-N-(thien-2-ylmethyl)pyridine-2-carboxamide KUC104244N_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

27 genes differentially expressed following the BRD-K28452084_N-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-N-(thien-2-ylmethyl)pyridine-2-carboxamide KUC104244N_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNPY3 canopy FGF signaling regulator 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein

decreased expression

Symbol Name
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BST2 bone marrow stromal cell antigen 2
CHPT1 choline phosphotransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
KIAA0101 KIAA0101
LITAF lipopolysaccharide-induced TNF factor
MCOLN1 mucolipin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RPL31 ribosomal protein L31