BRD-K28452084_N-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-N-(thien-2-ylmethyl)pyridine-2-carboxamide KUC104244N_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K28452084_N-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-N-(thien-2-ylmethyl)pyridine-2-carboxamide KUC104244N_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOD apolipoprotein D
ARG2 arginase 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL11A1 collagen, type XI, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
EPYC epiphycan
ESR1 estrogen receptor 1
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
GIMAP4 GTPase, IMAP family member 4
IFI16 interferon, gamma-inducible protein 16
IL6ST interleukin 6 signal transducer
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LPAR6 lysophosphatidic acid receptor 6
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MYLK myosin light chain kinase
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
RAB31 RAB31, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
STOM stomatin
TCL1B T-cell leukemia/lymphoma 1B
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM100 transmembrane protein 100
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VNN1 vanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
CA2 carbonic anhydrase II
CD44 CD44 molecule (Indian blood group)
CYC1 cytochrome c-1
DSP desmoplakin
EREG epiregulin
FNBP1 formin binding protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPI glucose-6-phosphate isomerase
GRB14 growth factor receptor-bound protein 14
LAMP5 lysosomal-associated membrane protein family, member 5
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MT1E metallothionein 1E
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
PLAGL1 pleiomorphic adenoma gene-like 1
PPIF peptidylprolyl isomerase F
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
RPL37A ribosomal protein L37a
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
TNS3 tensin 3
TRIP6 thyroid hormone receptor interactor 6
TUBA4A tubulin, alpha 4a
UGDH UDP-glucose 6-dehydrogenase
VCAN versican
ZIC1 Zic family member 1