BRD-K28307902_Flutamide_VCAP_6.0_h_28.96_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K28307902_Flutamide_VCAP_6.0_h_28.96_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CREB3L2 cAMP responsive element binding protein 3-like 2
FOXG1 forkhead box G1
FRZB frizzled-related protein
GNLY granulysin
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
IGL immunoglobulin lambda locus
MDFIC MyoD family inhibitor domain containing
MTSS1 metastasis suppressor 1
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPM2 tropomyosin 2 (beta)
TRIB1 tribbles pseudokinase 1

decreased expression

Symbol Name
C14ORF1 chromosome 14 open reading frame 1
C3 complement component 3
CLTB clathrin, light chain B
CST1 cystatin SN
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HK1 hexokinase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
KCTD5 potassium channel tetramerization domain containing 5
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLAT plasminogen activator, tissue
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SQLE squalene epoxidase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM41B transmembrane protein 41B