BRD-K28307902_Flutamide_RMUGS_6.0_h_28.96_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K28307902_Flutamide_RMUGS_6.0_h_28.96_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
BEX1 brain expressed, X-linked 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTSE cathepsin E
DSP desmoplakin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ICMT isoprenylcysteine carboxyl methyltransferase
KRT19 keratin 19, type I
MX2 MX dynamin-like GTPase 2
PFKL phosphofructokinase, liver
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
TF transferrin

decreased expression

Symbol Name
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO1A coronin, actin binding protein, 1A
DACH1 dachshund family transcription factor 1
EFS embryonal Fyn-associated substrate
EGR3 early growth response 3
EPHB2 EPH receptor B2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GSN gelsolin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
KIAA0485 uncharacterized LOC57235
KIF2C kinesin family member 2C
LCN2 lipocalin 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MSMO1 methylsterol monooxygenase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NUSAP1 nucleolar and spindle associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PRPF4 pre-mRNA processing factor 4
RAB40B RAB40B, member RAS oncogene family
RGCC regulator of cell cycle
RNF167 ring finger protein 167
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STOM stomatin
SYNM synemin, intermediate filament protein
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TNS1 tensin 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WWC1 WW and C2 domain containing 1