BRD-K28296557_Akt inhibitor IV_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKAP13 A kinase (PRKA) anchor protein 13
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
C6ORF62 chromosome 6 open reading frame 62
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CRYAB crystallin, alpha B
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
FAM129A family with sequence similarity 129, member A
GDF15 growth differentiation factor 15
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
IL32 interleukin 32
IL7R interleukin 7 receptor
JCHAIN joining chain of multimeric IgA and IgM
KLF5 Kruppel-like factor 5 (intestinal)
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
NCK2 NCK adaptor protein 2
NFIL3 nuclear factor, interleukin 3 regulated
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKN2 protein kinase N2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RB1CC1 RB1-inducible coiled-coil 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNNT1 troponin T type 1 (skeletal, slow)
TPR translocated promoter region, nuclear basket protein
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TTN titin
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZYX zyxin

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAM28 ADAM metallopeptidase domain 28
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAD BCL2-associated agonist of cell death
CD200 CD200 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLEC11A C-type lectin domain family 11, member A
CLIC4 chloride intracellular channel 4
COL4A2 collagen, type IV, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBP emopamil binding protein (sterol isomerase)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EXT1 exostosin glycosyltransferase 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GSTA4 glutathione S-transferase alpha 4
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LOC100505650 uncharacterized LOC100505650
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MLPH melanophilin
NRP1 neuropilin 1
PDHX pyruvate dehydrogenase complex, component X
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A7 S100 calcium binding protein A7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
TGFBI transforming growth factor, beta-induced, 68kDa
VCAM1 vascular cell adhesion molecule 1
Funding