BRD-K28180706_4-chloro-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K28180706_4-chloro-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALR calreticulin
CKAP4 cytoskeleton-associated protein 4
COL6A2 collagen, type VI, alpha 2
DAXX death-domain associated protein
DLK1 delta-like 1 homolog (Drosophila)
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESR1 estrogen receptor 1
FABP6 fatty acid binding protein 6, ileal
FAM129A family with sequence similarity 129, member A
GOLM1 golgi membrane protein 1
GPR161 G protein-coupled receptor 161
HBE1 hemoglobin, epsilon 1
HHEX hematopoietically expressed homeobox
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HOXB6 homeobox B6
HSPA2 heat shock 70kDa protein 2
KRT23 keratin 23, type I
LOC100286895 cell division cycle 27 homolog pseudogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAMLD1 mastermind-like domain containing 1
MEX3D mex-3 RNA binding family member D
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP11 matrix metallopeptidase 11
MXI1 MAX interactor 1, dimerization protein
NFE2 nuclear factor, erythroid 2
NID1 nidogen 1
OLFML2A olfactomedin-like 2A
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PLK2 polo-like kinase 2
PTK7 protein tyrosine kinase 7 (inactive)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFA transforming growth factor, alpha
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANGPT1 angiopoietin 1
ANXA3 annexin A3
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CFH complement factor H
CHMP4A charged multivesicular body protein 4A
COCH cochlin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GMNN geminin, DNA replication inhibitor
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPSM2 G-protein signaling modulator 2
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
IGLL1 immunoglobulin lambda-like polypeptide 1
IL18 interleukin 18
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KIAA0125 KIAA0125
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KYNU kynureninase
LACTB2 lactamase, beta 2
LDHB lactate dehydrogenase B
LPIN1 lipin 1
LUM lumican
LYPLA1 lysophospholipase I
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCOLN1 mucolipin 1
MEGF9 multiple EGF-like-domains 9
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
MYO5C myosin VC
NFIB nuclear factor I/B
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB4 phospholipase C, beta 4
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB40B RAB40B, member RAS oncogene family
REEP5 receptor accessory protein 5
RIT1 Ras-like without CAAX 1
S100A13 S100 calcium binding protein A13
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SMAD7 SMAD family member 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
STOM stomatin
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP4 TIMP metallopeptidase inhibitor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM50B transmembrane protein 50B
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
TXNDC9 thioredoxin domain containing 9
UBL3 ubiquitin-like 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WRB tryptophan rich basic protein
XPO7 exportin 7
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZEB2 zinc finger E-box binding homeobox 2