BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD163 CD163 molecule
COL4A5 collagen, type IV, alpha 5
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFNB2 ephrin-B2
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FTH1 ferritin, heavy polypeptide 1
GALC galactosylceramidase
GCLC glutamate-cysteine ligase, catalytic subunit
GRN granulin
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KYNU kynureninase
LGALS8 lectin, galactoside-binding, soluble, 8
LITAF lipopolysaccharide-induced TNF factor
MAOA monoamine oxidase A
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELL2 NEL-like 2 (chicken)
NT5DC2 5'-nucleotidase domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADAM12 ADAM metallopeptidase domain 12
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EDNRB endothelin receptor type B
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN2 fibulin 2
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FERMT2 fermitin family member 2
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPC3 glypican 3
HAS2 hyaluronan synthase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
MCUR1 mitochondrial calcium uniporter regulator 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
MRPS30 mitochondrial ribosomal protein S30
MSMO1 methylsterol monooxygenase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PRKCDBP protein kinase C, delta binding protein
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PVALB parvalbumin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SC5D sterol-C5-desaturase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMS spermine synthase
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
VCAN versican