BRD-K27630941_N-(2-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act01_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K27630941_N-(2-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act01_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DSG2 desmoglein 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FABP7 fatty acid binding protein 7, brain
FCHO1 FCH domain only 1
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGLL1 immunoglobulin lambda-like polypeptide 1
KRT14 keratin 14, type I
KRT16 keratin 16, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TPD52 tumor protein D52
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
BPHL biphenyl hydrolase-like (serine hydrolase)
CD46 CD46 molecule, complement regulatory protein
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHFR dihydrofolate reductase
DMD dystrophin
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HBB hemoglobin, beta
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIAA0101 KIAA0101
METTL7A methyltransferase like 7A
NID1 nidogen 1
OBSL1 obscurin-like 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PTK2 protein tyrosine kinase 2
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
VCAN versican
WFDC2 WAP four-disulfide core domain 2
ZNF652 zinc finger protein 652