BRD-K27316855_1,25-DIHYDROXYVITAMIN D3_HT29_24.0_h_1.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K27316855_1,25-DIHYDROXYVITAMIN D3_HT29_24.0_h_1.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADA adenosine deaminase
ADM adrenomedullin
ANGPT1 angiopoietin 1
ANPEP alanyl (membrane) aminopeptidase
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
BLVRB biliverdin reductase B
C1QA complement component 1, q subcomponent, A chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPNS1 calpain, small subunit 1
CD14 CD14 molecule
CREG1 cellular repressor of E1A-stimulated genes 1
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
FMO2 flavin containing monooxygenase 2 (non-functional)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTA4 glutathione S-transferase alpha 4
IDO1 indoleamine 2,3-dioxygenase 1
IQCG IQ motif containing G
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP10 matrix metallopeptidase 10
NDRG2 NDRG family member 2
NES nestin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PLBD1 phospholipase B domain containing 1
PMP22 peripheral myelin protein 22
PNPLA6 patatin-like phospholipase domain containing 6
PRF1 perforin 1 (pore forming protein)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPON2 spondin 2, extracellular matrix protein
TBC1D31 TBC1 domain family, member 31
TGM4 transglutaminase 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSKU tsukushi, small leucine rich proteoglycan
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCNE2 cyclin E2
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
COX7B cytochrome c oxidase subunit VIIb
CTSE cathepsin E
DACH1 dachshund family transcription factor 1
EIF5A eukaryotic translation initiation factor 5A
EVI2A ecotropic viral integration site 2A
FAM46A family with sequence similarity 46, member A
FGFR2 fibroblast growth factor receptor 2
GCA grancalcin, EF-hand calcium binding protein
GLIPR1 GLI pathogenesis-related 1
GPX1 glutathione peroxidase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HAL histidine ammonia-lyase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MPO myeloperoxidase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PKP4 plakophilin 4
PLN phospholamban
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNRPG small nuclear ribonucleoprotein polypeptide G
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM243 transmembrane protein 243, mitochondrial
TXNDC9 thioredoxin domain containing 9
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XIST X inactive specific transcript (non-protein coding)
Funding