BRD-K26838195_AST1306_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K26838195_AST1306_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BAD BCL2-associated agonist of cell death
CAPN1 calpain 1, (mu/I) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DEFB1 defensin, beta 1
DMTF1 cyclin D binding myb-like transcription factor 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
HIST1H2AC histone cluster 1, H2ac
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6R interleukin 6 receptor
LCN2 lipocalin 2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MN1 meningioma (disrupted in balanced translocation) 1
MSLN mesothelin
MSMB microseminoprotein, beta-
MUC1 mucin 1, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PLXNB1 plexin B1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACOX2 acyl-CoA oxidase 2, branched chain
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CD58 CD58 molecule
CD83 CD83 molecule
CDC42 cell division cycle 42
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CSRP1 cysteine and glycine-rich protein 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
IER3 immediate early response 3
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MT1X metallothionein 1X
MT2A metallothionein 2A
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
PPA1 pyrophosphatase (inorganic) 1
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
PTX3 pentraxin 3, long
SATB2 SATB homeobox 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARCL1 SPARC-like 1 (hevin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C