BRD-K25737009_-666_VCAP_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

232 genes differentially expressed following the BRD-K25737009_-666_VCAP_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
AHI1 Abelson helper integration site 1
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CALCOCO2 calcium binding and coiled-coil domain 2
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCPG1 cell cycle progression 1
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CTSS cathepsin S
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DESI2 desumoylating isopeptidase 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPRS glutamyl-prolyl-tRNA synthetase
EPS8 epidermal growth factor receptor pathway substrate 8
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
INHBE inhibin, beta E
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MLF1 myeloid leukemia factor 1
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MYO6 myosin VI
NARS asparaginyl-tRNA synthetase
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4DIP phosphodiesterase 4D interacting protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RSL24D1 ribosomal L24 domain containing 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFF1 trefoil factor 1
THBS3 thrombospondin 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATAD2 ATPase family, AAA domain containing 2
BLM Bloom syndrome, RecQ helicase-like
C14ORF169 chromosome 14 open reading frame 169
C3 complement component 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DEFA4 defensin, alpha 4, corticostatin
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GPX1 glutathione peroxidase 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MPHOSPH9 M-phase phosphoprotein 9
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
NCAPG non-SMC condensin I complex, subunit G
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCDH7 protocadherin 7
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRDX2 peroxiredoxin 2
RBM12 RNA binding motif protein 12
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SOAT1 sterol O-acyltransferase 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
STC1 stanniocalcin 1
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)