BRD-K25737009_-666_SKMEL28_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K25737009_-666_SKMEL28_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
COLEC12 collectin sub-family member 12
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELF4 E74-like factor 4 (ets domain transcription factor)
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
KRT19 keratin 19, type I
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
NFIL3 nuclear factor, interleukin 3 regulated
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
TRIB3 tribbles pseudokinase 3
TSPYL5 TSPY-like 5
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APMAP adipocyte plasma membrane associated protein
ASRGL1 asparaginase like 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BCHE butyrylcholinesterase
BST2 bone marrow stromal cell antigen 2
C5ORF30 chromosome 5 open reading frame 30
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CPVL carboxypeptidase, vitellogenic-like
CTSC cathepsin C
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERAP2 endoplasmic reticulum aminopeptidase 2
ERLIN2 ER lipid raft associated 2
EXT1 exostosin glycosyltransferase 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
GRN granulin
IQGAP2 IQ motif containing GTPase activating protein 2
LBR lamin B receptor
LTBP1 latent transforming growth factor beta binding protein 1
MARCKSL1 MARCKS-like 1
MEGF9 multiple EGF-like-domains 9
MFSD1 major facilitator superfamily domain containing 1
MYCBP MYC binding protein
NAV3 neuron navigator 3
NFIB nuclear factor I/B
NPC2 Niemann-Pick disease, type C2
NTS neurotensin
PODXL podocalyxin-like
PRDX1 peroxiredoxin 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
SACS sacsin molecular chaperone
SATB1 SATB homeobox 1
SEPHS1 selenophosphate synthetase 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKAP2 src kinase associated phosphoprotein 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C